Yes.
Type "LAYER" into the script filter (top right), and then select "Rename Layer" script.
;Block/Dimstyle/LAyer/LType/Style/Ucs/VIew/VPort
_RENAME
_LAYER
;THE NEXT LINE IS THE LAYER NAME TO REPLACE
OLD-NAME
;THE NEXT LINE IS THE NEW LAYER NAME
NEW-NAME
Repeat as necessary for as many layers as you like...
(You can click the "Append" checkbox between each click of the script, and it will append it after what is currently displayed in teh script editor window)
The download at http://www.74mph.com/hurricane.zip will let you try everything out.
Regards,
Bill